Postdoctoral Fellow
Location: Heidelberg, Germany
Staff Category: Postdoctoral Fellow
Contract Duration: 2 years
Grading: NA
Closing Date: 16 May 2021
Reference Number: HD01958
The Furlong group at EMBL, Heidelberg seek an ambitious postdoctoral fellow to lead an interdisciplinary project, focusing on heart organoids and single cell genomics. The appointed candidate will establish human cardioids, starting from iPS cells, and develop protocols that mimic both human heart development and genetic heart disease. The project is a close collaboration between the teams of Eileen Furlong (Head of Genome Biology, EMBL) and Johannes Backs (Head of Experimental Cardiology, Univ. of Heidelberg).  

Your role

The project entails working with our collaborators to establish and further develop protocols to differentiate human iPS cells into three-dimensional heart organoids. You will lead exciting studies using state-of-the-art single cell genomics methods, and spatial omics, to uncover the expression and regulatory changes during the in vitro development of a three-dimensional heart tube. Integrating in vivo data from human heart tissue, and bioimaging, will elucidate how well they mimic different stages of heart development and assess unexplored variation in developmental trajectories. This postdoctoral project is highly inter-disciplinary, and can be – depending on the qualification and the interests of the candidate – entirely experimental, or a “hybrid” experimental/computational biology. You will join a highly collaborative, diverse and international team  

You have

  • Candidates should hold a Ph.D. in a relevant field in life sciences.
  • The ideal candidate is a very skilled wet lab scientist with experience in mammalian cell culture, iPS cells, genomics, molecular biology, and genome engineering.
  • Experience in single cell approaches and/or expertise in computational biology is not mandatory, but would be an advantage.
  • We are looking for a ‘go getter’ candidate keen to tackle an exciting growing field, and one that works well with others, leveraging from the extensive expertise available to them.
  • The appointed candidate will be independent but also enjoy working in a friendly, collaborative lab and a very interdisciplinary setting.
  • The candidate should be motivated to build and maintain strong interactions with our collaborators and with the Furlong and Backs groups.
  • Candidates should be creative, ambitious and well-positioned to lead a scientific project at all stages, from experimental design to execution and manuscript preparation.
  • Fluency in English is essential.

You might also have

  • Hands-on experience with organoid cell culture models
  • Hands-on experience in iPS cell culture and genome editing
  • Experience in microscopy techniques
  • Experience in different single cell genomics methods (beyond scRNA-seq)
  • Interest in computational biology and/or data analysis
  • Experience in genomics data analyses e.g. using R or python

Why join us

The proposed project will provide the successful applicant with a great opportunity to develop expertise in the organoid field, in a model that has direct implications for both embryonic development and disease.  You will also gain expertise at the forefront of single cell genomics and spatial omics, and be able to lead this project in different directions. We are located in Heidelberg, which is a beautiful international city in the middle of Europe.  EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus

What else you need to know

EMBL is Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1800 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome. Our other missions are to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. The working language of the institute is English.