EMBL Barcelona, C/ Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain


  • PhD 2008, Kyoto University, Japan.
    Group leader, Career-Path Promotion Unit, Kyoto University, 2009-2013.
    Unit leader, RIKEN, Japan, 2013-2019.
    Group leader at EMBL Barcelona since 2018.
    ERC Investigator since 2021.


Total: 23 publication(s)


Matsuda M, Hayashi H, Garcia-Ojalvo J, Yoshioka-Kobayashi K, Kageyama R, Yamanaka Y, Ikeya M, Toguchida J, Alev C, Ebisuya M. (2020)

Species-specific segmentation clock periods are due to differential biochemical reaction speeds.

Science 369(6510):1450-1455. doi: 10.1126/science.aba7668
Europe PMC | doi

Tanaka N, Sekine R, Funano SI, Sato A, Carretero NT, Ebisuya M, Tanaka Y. (2020)

Vacuum microcasting of 2-methacryloyloxyethyl phosphorylcholine polymer for stable cell patterning.

Biotechniques doi: 10.2144/btn-2020-0052
Europe PMC | doi

Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, Ikeya M, Kawakami N, Yamamoto T, Woltjen K, Ebisuya M, Toguchida J, Alev C. (2020)

Recapitulating the human segmentation clock with pluripotent stem cells.

Nature 580(7801):124-129. doi: 10.1038/s41586-020-2144-9
Europe PMC | doi


Ebrahimkhani MR, Ebisuya M. (2019)

Synthetic developmental biology: build and control multicellular systems.

Curr Opin Chem Biol 52:9-15. doi: 10.1016/j.cbpa.2019.04.006
Europe PMC | doi


Ryoji Sekine, Tatsuo Shibata, Miki Ebisuya. (2018)

Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty

bioRxiv doi: 10.1101/372490
Europe PMC | doi

Sekine R, Shibata T, Ebisuya M. (2018)

Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty.

Nat Commun 9(1) doi: 10.1038/s41467-018-07847-x
Europe PMC | doi

Ebisuya M, Briscoe J. (2018)

What does time mean in development?

Development 145(12) doi: 10.1242/dev.164368
Europe PMC | doi


Lee J, Nakajima-Koyama M, Sone M, Koga M, Ebisuya M, Yamamoto T, Nishida E. (2015)

Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity Reduction.

Stem Cell Reports 5(4):480-9. doi: 10.1016/j.stemcr.2015.09.001
Europe PMC | doi

Matsuda M, Koga M, Woltjen K, Nishida E, Ebisuya M. (2015)

Synthetic lateral inhibition governs cell-type bifurcation with robust ratios.

Nat Commun 6 doi: 10.1038/ncomms7195
Europe PMC | doi

Imajo M, Ebisuya M, Nishida E. (2015)

Dual role of YAP and TAZ in renewal of the intestinal epithelium.

Nat Cell Biol 17(1):7-19. doi: 10.1038/ncb3084
Europe PMC | doi


Koga M, Matsuda M, Kawamura T, Sogo T, Shigeno A, Nishida E, Ebisuya M. (2014)

Foxd1 is a mediator and indicator of the cell reprogramming process.

Nat Commun 5 doi: 10.1038/ncomms4197
Europe PMC | doi


Takashima S, Hirose M, Ogonuki N, Ebisuya M, Inoue K, Kanatsu-Shinohara M, Tanaka T, Nishida E, Ogura A, Shinohara T. (2013)

Regulation of pluripotency in male germline stem cells by Dmrt1.

Genes Dev 27(18):1949-58. doi: 10.1101/gad.220194.113
Europe PMC | doi

Tanimura N, Saito M, Ebisuya M, Nishida E, Ishikawa F. (2013)

Stemness-related factor Sall4 interacts with transcription factors Oct-3/4 and Sox2 and occupies Oct-Sox elements in mouse embryonic stem cells.

J Biol Chem 288(7):5027-38. doi: 10.1074/jbc.M112.411173
Europe PMC | doi

Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, Ebisuya M, Yamamoto T, Matsumoto K, Nishida E. (2013)

A fasting-responsive signaling pathway that extends life span in C. elegans.

Cell Rep 3(1):79-91. doi: 10.1016/j.celrep.2012.12.018
Europe PMC | doi


Matsuda M, Koga M, Nishida E, Ebisuya M. (2012)

Synthetic signal propagation through direct cell-cell interaction.

Sci Signal 5(220) doi: 10.1126/scisignal.2002764
Europe PMC | doi

Matsumura S, Hamasaki M, Yamamoto T, Ebisuya M, Sato M, Nishida E, Toyoshima F. (2012)

ABL1 regulates spindle orientation in adherent cells and mammalian skin.

Nat Commun 3 doi: 10.1038/ncomms1634
Europe PMC | doi


Sunadome K, Yamamoto T, Ebisuya M, Kondoh K, Sehara-Fujisawa A, Nishida E. (2011)

ERK5 regulates muscle cell fusion through Klf transcription factors.

Dev Cell 20(2):192-205. doi: 10.1016/j.devcel.2010.12.005
Europe PMC | doi


Mitsushima M, Aoki K, Ebisuya M, Matsumura S, Yamamoto T, Matsuda M, Toyoshima F, Nishida E. (2010)

Revolving movement of a dynamic cluster of actin filaments during mitosis.

J Cell Biol 191(3):453-62. doi: 10.1083/jcb.201007136
Europe PMC | doi

Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S. (2010)

The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.

Mol Biol Cell 21(16):2953-65. doi: 10.1091/mbc.E09-10-0913
Europe PMC | doi


Ebisuya M, Yamamoto T, Nakajima M, Nishida E. (2008)

Ripples from neighbouring transcription.

Nat Cell Biol 10(9):1106-13. doi: 10.1038/ncb1771
Europe PMC | doi


Yamamoto T, Ebisuya M, Ashida F, Okamoto K, Yonehara S, Nishida E. (2006)

Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression.

Curr Biol 16(12):1171-82. doi: 10.1016/j.cub.2006.04.044
Europe PMC | doi


Ebisuya M, Kondoh K, Nishida E. (2005)

The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity.

J Cell Sci 118(Pt 14):2997-3002. doi: 10.1242/jcs.02505
Europe PMC | doi


Matsubayashi Y, Ebisuya M, Honjoh S, Nishida E. (2004)

ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing.

Curr Biol 14(8):731-5. doi: 10.1016/j.cub.2004.03.060
Europe PMC | doi