EMBL Barcelona, C/ Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain

Biography

  • PhD, 1997, MRC National Institute for Medical Research, London.
    Postdoctoral research fellow, 1998-2002, MRC Human Genetics Unit, Edinburgh.
    Group Leader, 2002-2206, MRC Human Genetics Unit, Edinburgh.
    Group Leader, Centre for Genomic Regulation (CRG), Barcelona, 2006-2017.
    Coordinator of Systems Biology Program, CRG, 2011-2017.
    Head of EMBL Barcelona since 2017.

Publications

Total: 88 publication(s)

2018

Martínez-Abadías N, Mateu Estivill R, Sastre Tomas J, Motch Perrine S, Yoon M, Robert-Moreno A, Swoger J, Russo L, Kawasaki K, Richtsmeier J, Sharpe J. (2018)

Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis.

Elife 7 doi: 10.7554/eLife.36405
Europe PMC | doi

Mayer J, Robert-Moreno A, Sharpe J, Swoger J. (2018)

Attenuation artifacts in light sheet fluorescence microscopy corrected by OPTiSPIM.

Light Sci Appl 7 doi: 10.1038/s41377-018-0068-z
Europe PMC | doi

Schaerli Y, Jiménez A, Duarte JM, Mihajlovic L, Renggli J, Isalan M, Sharpe J, Wagner A. (2018)

Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution.

Mol. Syst. Biol. 14(9)
Europe PMC

Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Fiocchi A, Kreutzfeldt M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV. (2018)

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.

J Exp Med 215(7):1869-1890. doi: 10.1084/jem.20170896
Europe PMC | doi

Diego X, Marcon L, Muller P, Sharpe J. (2018)

Key Features of Turing Systems are Determined Purely by Network Topology

Phys Rev X 8 doi: 10.1103/PhysRevX.8.021071
doi


2017

Abe J, Germann P, Ripoll J, Sharpe J, Stein JV. (2017)

Non-linear scaling of CD8(+) T cell responses by bystander DCs

CYTOKINE 100:48.

Sharpe J. (2017)

Computer modeling in developmental biology: growing today, essential tomorrow.

Development 144(23):4214-4225. doi: 10.1242/dev.151274
Europe PMC | doi

Okamoto E, Kusakabe R, Kuraku S, Hyodo S, Robert-Moreno A, Onimaru K, Sharpe J, Kuratani S, Tanaka M. (2017)

Migratory appendicular muscles precursor cells in the common ancestor to all vertebrates.

Nat Ecol Evol 1(11):1731-1736. doi: 10.1038/s41559-017-0330-4
Europe PMC | doi

Ackerknecht M, Gollmer K, Germann P, Ficht X, Abe J, Fukui Y, Swoger J, Ripoll J, Sharpe J, Stein JV. (2017)

Antigen Availability and DOCK2-Driven Motility Govern CD4(+) T Cell Interactions with Dendritic Cells In Vivo.

J Immunol 199(2) doi: 10.4049/jimmunol.1601148
Europe PMC | doi

Jiménez A, Cotterell J, Munteanu A, Sharpe J. (2017)

A spectrum of modularity in multi-functional gene circuits.

Mol Syst Biol 13(4):925. doi: 10.15252/msb.20167347
Europe PMC | doi


2016

Ozga AJ, Moalli F, Abe J, Swoger J, Sharpe J, Zehn D, Kreutzfeldt M, Merkler D, Ripoll J, Stein JV. (2016)

pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.

J Exp Med 213(12):2811-2829. doi: 10.1084/jem.20160206
Europe PMC | doi

Onimaru K, Marcon L, Musy M, Tanaka M, Sharpe J. (2016)

The fin-to-limb transition as the re-organization of a Turing pattern.

Nat Commun 7(711852) doi: 10.1038/ncomms11582
Europe PMC | doi

Marcon L, Diego X, Sharpe J, Müller P. (2016)

High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals.

Elife 5 doi: 10.7554/eLife.14022
Europe PMC | doi

Abe J, Ozga AJ, Swoger J, Sharpe J, Ripoll J, Stein JV. (2016)

Light sheet fluorescence microscopy for in situ cell interaction analysis in mouse lymph nodes.

J Immunol Methods 431:1-10. doi: 10.1016/j.jim.2016.01.015
Europe PMC | doi

Martínez-Abadías N, Mateu R, Niksic M, Russo L, Sharpe J. (2016)

Geometric Morphometrics on Gene Expression Patterns Within Phenotypes: A Case Example on Limb Development.

Syst Biol 65(2):194-211. doi: 10.1093/sysbio/syv067
Europe PMC | doi


2015

Cotterell J, Robert-Moreno A, Sharpe J. (2015)

A Local, Self-Organizing Reaction-Diffusion Model Can Explain Somite Patterning in Embryos.

Cell Syst 1(4):257-69. doi: 10.1016/j.cels.2015.10.002
Europe PMC | doi

Onimaru K, Kuraku S, Takagi W, Hyodo S, Sharpe J, Tanaka M. (2015)

A shift in anterior-posterior positional information underlies the fin-to-limb evolution.

Elife 4 doi: 10.7554/eLife.07048
Europe PMC | doi

Uzkudun M, Marcon L, Sharpe J. (2015)

Data-driven modelling of a gene regulatory network for cell fate decisions in the growing limb bud.

Mol Syst Biol 11(7) doi: 10.15252/msb.20145882
Europe PMC | doi

Schulze A, Gomez-Marin A, Rajendran VG, Lott G, Musy M, Ahammad P, Deogade A, Sharpe J, Riedl J, Jarriault D, Trautman ET, Werner C, Venkadesan M, Druckmann S, Jayaraman V, Louis M. (2015)

Dynamical feature extraction at the sensory periphery guides chemotaxis.

Elife 4 doi: 10.7554/eLife.06694
Europe PMC | doi

Saias L, Swoger J, D'Angelo A, Hayes P, Colombelli J, Sharpe J, Salbreux G, Solon J. (2015)

Decrease in Cell Volume Generates Contractile Forces Driving Dorsal Closure.

Dev. Cell 33(5) doi: 10.1016/j.devcel.2015.03.016
Europe PMC | doi

Green JB, Sharpe J. (2015)

Positional information and reaction-diffusion: two big ideas in developmental biology combine.

Development 142(7):1203-1211. doi: 10.1242/dev.114991
Europe PMC | doi

Jiménez A, Cotterell J, Munteanu A, Sharpe J. (2015)

Dynamics of gene circuits shapes evolvability.

Proc. Natl. Acad. Sci. U.S.A. 112(7):2103-8. doi: 10.1073/pnas.1411065112
Europe PMC | doi

Agustí A, Antó JM, Auffray C, Barbé F, Barreiro E, Dorca J, Escarrabill J, Faner R, Furlong LI, Garcia-Aymerich J, Gea J, Lindmark B, Monsó E, Plaza V, Puhan MA, Roca J, Ruiz-Manzano J, Sampietro-Colom L, Sanz F, Serrano L, Sharpe J, Sibila O, Silverman EK, Sterk PJ, Sznajder JI. (2015)

Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014.

Am J Respir Crit Care Med 191(4):391-401. doi: 10.1164/rccm.201410-1935PP
Europe PMC | doi


2014

Sharpe J. (2014)

Developmental biology: Cells unite by trapping a signal.

Nature 515(7525):41-42. doi: 10.1038/nature13933
Europe PMC | doi

Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Bénazet JD, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, Butcher S, Manak JR, Vaccari T, Weinstein H, Anderson KV, Lacy E, Selleri L. (2014)

ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling.

Cell Rep 9(2):674-687. doi: 10.1016/j.celrep.2014.09.019
Europe PMC | doi

Schaerli Y, Munteanu A, Gili M, Cotterell J, Sharpe J, Isalan M. (2014)

A unified design space of synthetic stripe-forming networks.

Nat Commun 5 doi: 10.1038/ncomms5905
Europe PMC | doi

Jaeger J, Sharpe J. (2014)

On the concept of mechanism in development

In: Minelli A., Towards a Theory of Development. Oxford University Press, Oxford.doi: 10.1093/acprof:oso/9780199671427.003.0004
doi

Raspopovic J, Marcon L, Russo L, Sharpe J. (2014)

Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients.

Science 345(6196):566-570. doi: 10.1126/science.1252960
Europe PMC | doi

Nowlan NC, Chandaria V, Sharpe J. (2014)

Immobilized chicks as a model system for early-onset developmental dysplasia of the hip.

J. Orthop. Res. 32(6):777-785. doi: 10.1002/jor.22606
Europe PMC | doi

Munteanu A, Cotterell J, Solé RV, Sharpe J. (2014)

Design principles of stripe-forming motifs: the role of positive feedback.

Sci Rep 4 doi: 10.1038/srep05003
Europe PMC | doi

Nowlan NC, Sharpe J. (2014)

Joint shape morphogenesis precedes cavitation of the developing hip joint.

J. Anat. 224(4):482-489. doi: 10.1111/joa.12143
Europe PMC | doi

Mayer J, Robert-Moreno A, Danuser R, Stein JV, Sharpe J, Swoger J. (2014)

OPTiSPIM: integrating optical projection tomography in light sheet microscopy extends specimen characterization to nonfluorescent contrasts.

Opt Lett 39(4):1053-1056. doi: 10.1364/OL.39.001053
Europe PMC | doi


2013

Allena R, Aubry D, Sharpe J. (2013)

On the mechanical interplay between intra- and inter-synchronization during collective cell migration: a numerical investigation.

Bull. Math. Biol. 75(12):2575-2599. doi: 10.1007/s11538-013-9908-4
Europe PMC | doi

Degenkolbe E, König J, Zimmer J, Walther M, Reißner C, Nickel J, Plöger F, Raspopovic J, Sharpe J, Dathe K, Hecht JT, Mundlos S, Doelken SC, Seemann P. (2013)

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2.

PLoS Genet. 9(10) doi: 10.1371/journal.pgen.1003846
Europe PMC | doi

Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, Yosef R, Pilpel N, Krizhanovsky V, Sharpe J, Keyes WM. (2013)

Senescence is a developmental mechanism that contributes to embryonic growth and patterning.

Cell 155(5):1119-1130. doi: 10.1016/j.cell.2013.10.041
Europe PMC | doi

Pinto-Teixeira F, Muzzopappa M, Swoger J, Mineo A, Sharpe J, López-Schier H. (2013)

Intravital imaging of hair-cell development and regeneration in the zebrafish.

Front Neuroanat 7(33) doi: 10.3389/fnana.2013.00033
Europe PMC | doi

Coelho FM, Natale D, Soriano SF, Hons M, Swoger J, Mayer J, Danuser R, Scandella E, Pieczyk M, Zerwes HG, Junt T, Sailer AW, Ludewig B, Sharpe J, Figge MT, Stein JV. (2013)

Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions.

Blood 121(20):4101-4109. doi: 10.1182/blood-2012-10-465336
Europe PMC | doi

Cotterell J, Sharpe J. (2013)

Mechanistic explanations for restricted evolutionary paths that emerge from gene regulatory networks.

PLoS ONE 8(4) doi: 10.1371/journal.pone.0061178
Europe PMC | doi

Sanders PG, Cotterell J, Sharpe J, Isalan M. (2013)

Transfecting RNA quadruplexes results in few transcriptome perturbations.

RNA Biol 10(2):205-210. doi: 10.4161/rna.22781
Europe PMC | doi

Eriksson AU, Svensson C, Hornblad A, Cheddad A, Kostromina E, Eriksson M, Norlin N, Pileggi A, Sharpe J, Georgsson F, Alanentalo T, Ahlgren U. (2013)

Near Infrared Optical Projection Tomography for Assessments of beta-cell Mass Distribution in Diabetes Research

J Vis Exp (71) doi: 10.3791/50238
Europe PMC | doi

Eriksson AU, Svensson C, Hörnblad A, Cheddad A, Kostromina E, Eriksson M, Norlin N, Pileggi A, Sharpe J, Georgsson F, Alanentalo T, Ahlgren U. (2013)

Near infrared optical projection tomography for assessments of β-cell mass distribution in diabetes research.

J Vis Exp (71) doi: 10.3791/50238
Europe PMC | doi


2012

Marcon L, Sharpe J. (2012)

Turing patterns in development: what about the horse part?

Curr. Opin. Genet. Dev. 22(6):578-584. doi: 10.1016/j.gde.2012.11.013
Europe PMC | doi

Sheth R, Marcon L, Bastida MF, Junco M, Quintana L, Dahn R, Kmita M, Sharpe J, Ros MA. (2012)

Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism.

Science 338(6113):1476-1480. doi: 10.1126/science.1226804
Europe PMC | doi

Mayer J, Swoger J, Ozga AJ, Stein JV, Sharpe J. (2012)

Quantitative measurements in 3-dimensional datasets of mouse lymph nodes resolve organ-wide functional dependencies.

Comput Math Methods Med 2012 doi: 10.1155/2012/128431
Europe PMC | doi

Olarte OE, Licea-Rodriguez J, Palero JA, Gualda EJ, Artigas D, Mayer J, Swoger J, Sharpe J, Rocha-Mendoza I, Rangel-Rojo R, Loza-Alvarez P. (2012)

Image formation by linear and nonlinear digital scanned light-sheet fluorescence microscopy with Gaussian and Bessel beam profiles.

Biomed Opt Express 3(7):1492-1505. doi: 10.1364/BOE.3.001492
Europe PMC | doi

Cheddad A, Svensson C, Sharpe J, Georgsson F, Ahlgren U. (2012)

Image processing assisted algorithms for optical projection tomography.

IEEE Trans Med Imaging 31(1):1-15. doi: 10.1109/TMI.2011.2161590
Europe PMC | doi


2011

Sharpe J. (2011)

Two ways to use imaging: focusing directly on mechanism, or indirectly via behaviour?

Curr. Opin. Genet. Dev. 21(5):523-529. doi: 10.1016/j.gde.2011.08.012
Europe PMC | doi

Quintana L, Sharpe J. (2011)

Optical projection tomography of vertebrate embryo development.

Cold Spring Harb Protoc 2011(6):586-594. doi: 10.1101/pdb.top116
Europe PMC | doi

Capellini TD, Handschuh K, Quintana L, Ferretti E, Di Giacomo G, Fantini S, Vaccari G, Clarke SL, Wenger AM, Bejerano G, Sharpe J, Zappavigna V, Selleri L. (2011)

Control of pelvic girdle development by genes of the Pbx family and Emx2.

DEV DYNAM 240(5):1173-1189. doi: 10.1002/dvdy.22617
Europe PMC | doi

Hopyan S, Sharpe J, Yang YZ. (2011)

Budding Behaviors: Growth of the Limb as a Model of Morphogenesis

DEV DYNAM 240(5):1054-1062. doi: 10.1002/dvdy.22601
Europe PMC | doi

Boehm B, Rautschka M, Quintana L, Raspopovic J, Jan Z, Sharpe J. (2011)

A landmark-free morphometric staging system for the mouse limb bud.

DEVELOPMENT 138(6):1227-1234. doi: 10.1242/dev.057547
Europe PMC | doi

Marcon L, Arqués CG, Torres MS, Sharpe J. (2011)

A computational clonal analysis of the developing mouse limb bud.

PLOS COMPUT BIOL 7(2):1-16. doi: 10.1371/journal.pcbi.1001071
Europe PMC | doi

Sharpe J, Wong R, Yuste R. (2011)

Imaging in Developmental Biology

Cold Spring Harbor Laboratory Press’ Imaging series. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.

Swoger J, Muzzopappa M, Lopez-Schier H, Sharpe J. (2011)

4D retrospective lineage tracing using SPIM for zebrafish organogenesis studies

J BIOPHOTONICS 4(1-2):122-134. doi: 10.1002/jbio.201000087
Europe PMC | doi


2010

Cotterell J, Sharpe J. (2010)

An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients

MOL SYST BIOL 6 doi: 10.1038/msb.2010.74
Europe PMC | doi

Nowlan NC, Sharpe J, Roddy KA, Prendergast PJ, Murphy P. (2010)

Mechanobiology of embryonic skeletal development: Insights from animal models.

BIRTH DEFECTS RES C 90(3):203-213. doi: 10.1002/bdrc.20184
Europe PMC | doi

Capellini TD, Vaccari G, Ferretti E, Fantini S, He M, Pellegrini M, Quintana L, Di Giacomo G, Sharpe J, Selleri L, Zappavigna V. (2010)

Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1

DEVELOPMENT 137(15):2559-2569. doi: 10.1242/dev.048819
Europe PMC | doi

Boehm B, Westerberg H, Lesnicar-Pucko G, Raja S, Rautschka M, Cotterell J, Swoger J, Sharpe J. (2010)

The role of spatially controlled cell proliferation in limb bud morphogenesis.

PLOS BIOL 8(7) doi: 10.1371/journal.pbio.1000420
Europe PMC | doi

Alanentalo T, Hornblad A, Mayans S, Nilsson AK, Sharpe J, Larefalk A, Ahlgren U, Holmberg D. (2010)

Quantification and Three-Dimensional Imaging of the Insulitis-Induced Destruction of beta-Cells in Murine Type 1 Diabetes

DIABETES 59(7):1756-1764. doi: 10.2337/db09-1400
Europe PMC | doi

Jimenez-Guri E, Udina F, Colas JF, Sharpe J, Padrón-Barthe L, Torres M, Pujades C. (2010)

Clonal Analysis in Mice Underlines the Importance of Rhombomeric Boundaries in Cell Movement Restriction during Hindbrain Segmentation

PLOS ONE 5(4):1-7. doi: 10.1371/journal.pone.0010112
Europe PMC | doi


2009

Colas JF, Sharpe J. (2009)

Live optical projection tomography.

Organogenesis 5(4):211-216. doi: 10.4161/org.5.4.10426
Europe PMC | doi

Lemos MC, Harding B, Reed AAC, Jeyabalan J, Walls GV, Bowl MR, Sharpe J, Wedden S, Moss JE, Ross A, Davidson D, Thakker RV. (2009)

Genetic background influences embryonic lethality and the occurrence of neural tube defects in Men1 null mice: relevance to genetic modifiers

J ENDOCRINOL 203(1):133-142. doi: 10.1677/JOE-09-0124
Europe PMC | doi

Vendrell V, Summerhurst K, Sharpe J, Davidson D, Murphy P. (2009)

Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo

GENE EXPR PATTERNS 9(5):296-305. doi: 10.1016/j.gep.2009.03.001
Europe PMC | doi

Hajihosseini MK, Duarte R, Pegrum J, Donjacour A, Lana-Elola E, Rice DP, Sharpe J, Dickson C. (2009)

Evidence That Fgf10 Contributes to the Skeletal and Visceral Defects of an Apert Syndrome Mouse Model

DEV DYNAM 238(2):376-385. doi: 10.1002/dvdy.21648
Europe PMC | doi


2008

Alanentalo T, Loren CE, Larefalk A, Sharpe J, Holmberg D, Ahlgren U. (2008)

High-resolution three-dimensional imaging of islet-infiltrate interactions based on optical projection tomography assessments of the intact adult mouse pancreas

J BIOMED OPT 13(5) doi: 10.1117/1.3000430
Europe PMC | doi

McGinty J, Tahir KR, Laine R, Talbot CB, Dunsby C, Neil MAA, Quintana L, Swoger J, Sharpe J, French PMW. (2008)

Fluorescence lifetime optical projection tomography

J BIOPHOTONICS 1(5):390-394. doi: 10.1002/jbio.200810044
Europe PMC | doi

Boot MJ, Westerberg CH, Sanz-Ezquerro J, Cotterell J, Schweitzer R, Torres M, Sharpe J. (2008)

In vitro whole-organ imaging: 4D quantification of growing mouse limb buds

NAT METHODS 5(7):609-612. doi: 10.1038/nmeth.1219
Europe PMC | doi

Summerhurst K, Stark M, Sharpe J, Davidson D, Murphy P. (2008)

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19)

GENE EXPR PATTERNS 8(5):331-348. doi: 10.1016/j.gep.2008.01.007
Europe PMC | doi

Hajihosseini MK, De Langhe S, Lana-Elola E, Morrison H, Sparshott N, Kelly R, Sharpe J, Rice D, Bellusci S. (2008)

Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis

MOL CELL NEUROSCI 37(4):857-868. doi: 10.1016/j.mcn.2008.01.008
Europe PMC | doi


2007

Arques CG, Doohan R, Sharpe J, Torres M. (2007)

Cell tracing reveals a dorsoventral lineage restriction plane in the mouse limb bud mesenchyme

DEVELOPMENT 134(20):3713-3722. doi: 10.1242/dev.02873
Europe PMC | doi

McGurk L, Morrison H, Keegan LP, Sharpe J, O'Connell MA. (2007)

Three-Dimensional Imaging of Drosophila melanogaster

PLOS ONE 2(9) doi: 10.1371/journal.pone.0000834
Europe PMC | doi

Bryson-Richardson RJ, Berger S, Schilling TF, Hall TE, Cole NJ, Gibson AJ, Sharpe J, Currie PD. (2007)

FishNet: an online database of zebrafish anatomy

BMC BIOL 5 doi: 10.1186/1741-7007-5-34
Europe PMC | doi

Walls JR, Sled JG, Sharpe J, Henkelman RM. (2007)

Resolution improvement in emission optical projection tomography

PHYS MED BIOL 52(10):2775-2790. doi: 10.1088/0031-9155/52/10/010
Europe PMC | doi


2006

Alanentalo T, Asayesh A, Morrison H, Loren CE, Holmberg D, Sharpe J, Ahlgren U. (2006)

Tomographic molecular imaging and 3D quantification within adult mouse organs

NAT METHODS 4(1):31-33. doi: 10.1038/NMETH985
Europe PMC | doi

Lee K, Avondo J, Morrison H, Blot L, Stark M, Sharpe J, Bangham A, Coen E. (2006)

Visualizing plant development and gene expression in three dimensions using optical projection tomography.

PLANT CELL 18(9):2145-2156. doi: 10.1105/tpc.106.043042
Europe PMC | doi

Asayesh A, Sharpe J, Watson RP, Hecksher-Sørensen J, Hastie ND, Hill RE, Ahlgren U. (2006)

Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.

Genes Dev 20(16):2208-2213. doi: 10.1101/gad.381906
Europe PMC | doi


2005

Walls JR, Sled JG, Sharpe J, Henkelman RM. (2005)

Correction of artefacts in optical projection tomography

PHYS MED BIOL 50(19):4645-4665. doi: 10.1088/0031-9155/50/19/015
Europe PMC | doi

Sarma S, Kerwin J, Puelles L, Scott M, Strachan T, Feng G, Sharpe J, Davidson D, Baldock R, Lindsay S. (2005)

3D modelling, gene expression mapping and post-mapping image analysis in the developing human brain.

Brain Res Bull 66(4-6):449-453. doi: 10.1016/j.brainresbull.2005.05.022
Europe PMC | doi


2004

Kerwin J, Scott M, Sharpe J, Puelles L, Robson SC, Martinez-de-la-Torre M, Ferran JL, Feng GJ, Baldock R, Strachan T, Davidson D, Lindsay S. (2004)

3 dimensional modelling of early human brain development using optical projection tomography

BMC NEUROSCI 5 doi: 10.1186/1471-2202-5-27
Europe PMC | doi

Sharpe J. (2004)

Optical projection tomography.

Annu Rev Biomed Eng 6:209-228. doi: 10.1146/annurev.bioeng.6.040803.140210
Europe PMC | doi

Wilkie AL, Jordan SA, Sharpe JA, Price DJ, Jackson IJ. (2004)

Widespread tangential dispersion and extensive cell death during early neurogenesis in the mouse neocortex

DEV BIOL 267(1):109-118. doi: 10.1016/j.ydbio.2003.11.006
Europe PMC | doi


2003

Sharpe J. (2003)

Optical projection tomography as a new tool for studying embryo anatomy

J ANAT 202(2):175-181. doi: 10.1046/j.1469-7580.2003.00155.x
Europe PMC | doi


2002

Sharpe J, Ahlgren U, Perry P, Hill B, Ross A, Hecksher-Sorensen J, Baldock R, Davidson D. (2002)

Optical projection tomography as a tool for 3D microscopy and gene expression studies

SCIENCE 296(5567):541-545. doi: 10.1126/science.1068206
Europe PMC | doi


2001

Hecksher-Sorensen J, Sharpe J. (2001)

3D confocal reconstruction of gene expression in mouse

MECH DEVELOP 100(1):59-63. doi: 10.1016/S0925-4773(00)00508-6
Europe PMC | doi


1999

Sharpe J, Lettice L, Hecksher-Sorensen J, Fox M, Hill R, Krumlauf R. (1999)

Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch.

CURR BIOL 9(2):97-100. doi: 10.1016/S0960-9822(99)80022-0
Europe PMC | doi


1998

Sharpe J, Nonchev S, Gould A, Whiting J, Krumlauf R. (1998)

Selectivity, sharing and competitive interactions in the regulation of Hoxb genes

EMBO J 17(6):1788-1798. doi: 10.1093/emboj/17.6.1788
Europe PMC | doi


1996

Itasaki N, Sharpe J, Morrison A, Krumlauf R. (1996)

Reprogramming Hox expression in the vertebrate hindbrain: Influence of paraxial mesoderm and rhombomere transposition

Neuron 16(3):487-500. doi: 10.1016/S0896-6273(00)80069-0
Europe PMC | doi


1993

Sharpe JA, Day A. (1993)

Structure, evolution and expression of the mitochondrial ADP/ATP translocator gene from Chlamydomonas reinhardtii.

Mol Gen Genet 237(1-2):134-144. doi: 10.1007/BF00282794
Europe PMC | doi