Location & dates EMBL Barcelona, Spain 2 - 5 Jul 2019
Deadlines Registration closed Abstract submission closed

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Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.

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Day 1 - Tuesday 2 July 2019
11:30-13:15 Arrival and Registration
12:30-13:00 Pre-Conference Workshop
13:15-13:30 Opening Remarks

Keynote Lecture I
In vivo studies of human genome function

Len Pennacchio - DOE Joint Genome Institute, USA


Session 1 - Gene Regulation
Chair: Rolf Zeller


HoxA13 and HoxD13 function as pioneer factors in the developing limb
Marie Kmita - McGill University, Canada


Robustness versus evolvability: Transcriptional control of the BMP antagonist Grem1 during vertebrate limb development
Aimée Zuniga - University of Basel, Switzerland


Coffee break

15:50-16:15 LIMB-NET: An online simulation tool for the limb development community
James Sharpe - EMBL Barcelona, Spain

Long-range gene regulation at the HoxD locus during limb development
Denis Duboule - University of Geneva, Switzerland


Two Lmx1b-associated cis-regulatory modules (LARM1/2) mediate Lmx1b auto-amplification during limb dorsalization and their disruption can cause a limb-specific form of Nail-Patella syndrome
Kerby Oberg - Loma Linda University, USA

16:55-17:10 Limb development through the lens of single-cell analysis
Sveta Markman - Weizmann Institute of Science, Israel
17:10-17:25 GLI transcriptional repression regulates enhancer activity and chromatin accessibility in response to Hedgehog signaling
Steven Vokes - University of Texas at Austin, USA
17:25-19:00 Welcome reception on PRBB Terrace
Day 2 - Wednesday 3 July 2019
09:00-12:10 Session 2 - Patterning
Chair: Gary Schoenwolf

Appropriate spatial restriction of cell signalling in the developing limb: Integration of mechanical cues
Paula Murphy - Trinity College Dublin, Ireland


Early Shh function and the late determination of digit identity:  Temporal integration by multiple signals
Susan Mackem - National Cancer Institute, USA


Meis transcription factors interpret FGF signaling gradient to convey positional information along the limb bud proximo-distal axis
Irene Delgado - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain


Differential response of the developing limb neuromuscular system to an altered autopod pattern
Maëva Luxey - University of Basel, Switzerland

10:20-10:50 Coffee break

SP8-dependent regulatory network in the limb ectoderm
Marian Ros - CSIC, University of Cantabria, Spain


Regulation of the formation and maintenance of limb muscle and bone tissue
Malcolm Logan - King's College London, United Kingdom


Reprogramming non-limb fibroblasts into limb bud progenitor-like cells
Yuji Atsuta - Harvard Medical School, USA


Molecular mechanism of segmentation of limb cartilage
Amitabha Bandyopadhyay - Indian Institute of Technology Kanpur, India




Session 3 - Patterning & Regeneration
Chair: Gregg Duester


Recruiting progenitor cells during development, wound healing, and regeneration
Joshua D. Currie - University of Toronto, Canada


Overcoming regenerative restrictions in mice
Ken Muneoka - Texas A&M University, USA


How do axolotls memorize and regulate the patterning information in limb regeneration
Akane Kawaguchi - Research Institute of Molecular Pathology (IMP), Austria


Single-cell profiling of the regenerating axolotl limb
Nicholas D Leigh - Harvard University, USA


Coffee break


Maintenance of genomic integrity in proliferating blastema cells of regenerating axolotl limbs
Jessica Whited - Harvard University, USA

16:15-16:40 Re-patterning and re-sizing in regeneration of vertebrate appendages
Koji Tamura - Tohoku University, Japan

EGFR activation promotes regenerative capacity in mouse digit tissue
Caroline Dealy - UConn Health, USA

16:55-17:10 Functional analysis for deciphering unique genetic program in newt limb regeneration
Miyuki Suzuki - National Institute for Basic Biology, Japan
17:10-17:40 Flash Talk Session I
Poster No: 55, 59, 63, 65, 67, 71, 85, 89, 91

Poster Session I (odd numbers)

19:00-20:00 Keynote Lecture II
Limb regeneration - a non-conserved, conserved process
Elly Tanaka - IMP - Research Institute of Molecular Pathology, Austria
Day 3 - Thursday 4 July 2019
09:00-12:10 Session 4 - Morphogenesis & Modelling
Chair: Miguel Torres
09:00-09:25 Insights into the dynamics of limb chondrogenesis
Jérôme Gros - Institut Pasteur, France

Quantitative and comparative analysis of tissue deformation dynamics during chick and Xenopus limb development
Yoshihiro Morishita - RIKEN Center for Biosystems Dynamics Research, Japan

09:50-10:05 Sonic Hedgehog (Shh) does not act as a limb morphogen but is required to specify all digit types, including digit 1 (thumb)
Jianjian Zhu - National Cancer Institute, USA
10:05-10:20 A 3D computer simulation of limb morphogenesis
Miquel Marin-Riera - EMBL Barcelona, Spain
10:20-10:50 Coffee break

Biophysical approaches to morphogenesis in the mouse embryo
Sevan Hopyan - University of Toronto, Canada

11:15-11:30 Modulating Wnt-dependent transcriptional processes and morphologies during
mammalian organogenesis
Rushikesh Sheth - University of Basel, Switzerland

Development of the pelvic girdle requires apical ectodermal ridge FGFs
Christian Louis Bonatto Paese - National Cancer Institute, USA


A new role of GDF5 in regulating cell and nuclear morphology during chondrocyte differentiation
Sarah Rubin - Weizmann Institute of Science, Israel




Session 5 - Growth
Chair: Elazar Zelzer


The control of tempo during embryonic development: insights from limb development
Megan Davey - The University of Edinburgh, United Kingdom


Different insults to long bone growth lead to distinct scaling effects in developing mice
Alberto Roselló-Díez - Monash University, Australia


3D Visualisation of the role of cell activities in joint morphogenesis
Yuming Huang - Imperial College London, United Kingdom


Pectoral fin morphogenesis: From a monolayer to a 3D structure
Hahn Nguyen - CNRS USR3695 BioEmergences, France


Coffee break


ECM collagens in the prenatal skeletal rudiment: How do they develop and are they mechanoregulated?
Niamh Nowlan - Imperial College London, United Kingdom


Thalidomide-induced limb differences: The role of the blood vessels
Neil Vargesson - University of Aberdeen, United Kingdom


Shh mediated Fgf-signaling is compartmentalized in the mesenchyme and controls limb size during salamander development
Sruthi Purushothaman - University of Kentucky, USA

16:55-17:25 Flash Talk Session II
Poster No: 50, 52, 58, 60, 72, 74, 90, 100, 108, 112
17:25-19:00 Poster Session II (even numbers)
19:00-22:00 Conference dinner at Marina Bay
Day 4 - Friday 5 July 2019
09:00-11:55 Session 6 - Evolution
Chair: Jacques Drouin

Developmental basis of mammalian limb variation
Karen E. Sears - University of California, Los Angeles, USA


What big feet you have! Development and evolution of limb skeletal proportion
Kimberly Cooper - UCSD, USA


Developmental basis of limb heterochrony in the wing of the emu (Dromaius novaehollandiae)
John Young - Harvard Medical School, USA


A developmental mechanism for metapterygial bending during the evolution of the tetrapod limb
Joost Woltering - University of Konstanz, Germany


Group photo

10:20-10:45 Coffee break
10:45-11:10 HoxD13 and its targets and the evolution of vertebrate limbs
Renata Freitas - IBMC, Portugal

Left-right asymmetric reduction of skeletal elements in emu wings
Mikiko Tanaka - Tokyo Institute of Technology, Japan


Working material for appendage variation: Potential to form limb-like skeletal structures in zebrafish by activation of a latent patterning mechanism
Brent Hawkins - Harvard Medical School/Boston Children's Hospital, USA


Dissecting the cis-regulatory robustness of Ptch1 in limb development and evolution
Virginie Tissières - Centro Andaluz de Biología del Desarrollo, CSIC, Spain


Keynote Lecture III
Are Hox-expressing cells musculoskeletal stem cells?

Deneen M. Wellik - University of Wisconsin-Madison, USA

12:55-13:15 Poster Prize Award Ceremony and Closing Remarks